Author

C. Munro

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Open access Nov 2026

Fungal suppression by bacterial metabolite-activated human intestinal γδT-cells is disrupted in Crohn's disease.

Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacterial metabolite HMB-PP is sensed by a specialized population of Vγ9Vδ2+T-cells, which we now report can potently suppress...

L. Mathew, S. Carlson, M. Savage et al. · PLoS Biology · 0 citations

Open access Sep 2026

Outbreaks of fluconazole-resistant Candida parapsilosis are driven by low-biofilm-producing isolates that emerge under host selection

It is shown that FLCR-Cp isolates responsible for prolonged, multi-country outbreaks consistently exhibit a striking low-biofilm-producing (LBP) phenotype, overturning the assumption that robust biofilm formation drives outbreak persistence and identifying biofilm attenuation as an adaptive tradeoff that promotes immun...

F. Daneshnia, Deepika Gunasekaran, S. Bergin et al. · PLoS Biology · 2 citations · ⚡1