Plants have evolved adaptive mechanisms to handle environmental stress. However, Genome-Wide-Association-Studies have identified genetic variations associated with stress resistance, yet their structural and functional impacts remain poorly understood. This limits our ability to develop more resilient crops....
Fatima Shahid, Neeladri Sen, C. Orengo et al.· Bioinformatics Advances· 0 citations
Protein structure prediction has expanded structural databases to hundreds of millions of domains. Classifying these domains into homologous superfamilies reveals evolutionary and functional relationships that can persist despite low sequence similarity. As the size of structural databases continues to grow, homology c...
David Miller, Nicola Bordin, Janusan Jeyananthan et al.· bioRxiv· 0 citations
A characterization of a large subset of PAAT enzymes, including their likely oligomeric states, functional site properties, and experimental functions is presented, including their likely oligomeric states, functional site properties, and experimental functions.
J. Roca-Martínez, Hazel N. Leiva Martel, Jialin Yin et al.· Structure· 0 citations
De novo protein design is advancing rapidly1,2. This is being driven by AI to generate protein backbones, sequences, and structural models3–7. As a result, de novo designed proteins are becoming larger and more complex8–10, and increasingly explore new protein structures11,12. By contrast, natural proteins have evolved...
K. I. Albanese, Joel J. Chubb, L. Gutierrez-Rus et al.· bioRxiv· 0 citations
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