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Author

C. O'Sullivan

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Review Open access Oct 2026

The evolving treatment of HER2-positive early breast cancer

HER2-positive early breast cancer (EBC) accounts for 15–20% of breast cancer cases and is characterized by aggressive biology, though outcomes have significantly improved with HER2-directed therapies. This narrative review summarizes contemporary approaches to personalize systemic treatment of HER2-positive EBC through...

C. O'Sullivan · 0 citations
Aug 2026

Pathologic Complete Response (pCR) Rate and Predictors of Response to Taxane, Trastuzumab, and Pertuzumab in HER2‑Positive Breast Cancer: Secondary Analyses of EA1181/CompassHER2 pCR.

PURPOSE EA1181 (ClinicalTrials.gov identifier: NCT04266249) is a single-arm trial evaluating neoadjuvant taxane, trastuzumab, and pertuzumab (THP) in patients with clinical stage II/IIIa human epidermal growth factor receptor 2 (HER2)-positive breast cancer. This report focuses on the secondary end points of pathologic...

N. Tung, Feng-Min Zhao, A. DeMichele et al. · 1 citation
Review Open access Oct 2026

Treatment of Breast Cancer.

Breast cancer (BC) is the most frequently diagnosed cancer among women and the leading cause of cancer deaths in females globally. In the United States, more than 300,000 new cases of invasive BC are diagnosed annually, and more than 40,000 patients die of metastatic BC. Herein, we discuss the current and evolving mana...

Kathryn J. Ruddy, D. Idossa, Dalliah M. Black et al. · 0 citations

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