C. Pawlow

Single-cell and spatial transcriptomics resolve airway obliteration in bronchiolitis obliterans syndrome

Background Chronic lung allograft dysfunction (CLAD) is the leading cause of death beyond the first year after lung transplantation, and its most frequent phenotype is bronchiolitis obliterans syndrome (BOS), a fibrotic small-airway disease. Mechanistic work has focused on the immune compartment, yet intensified immuno...