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Author

C. Pawlyn

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Review Oct 2026

Real-World Experience of Using Next-Generation-Sequencing in Multiple Myeloma Diagnostics in the UK National Health Service.

The IMS-IMWG 2025 updated definition of high-risk multiple myeloma (HRMM) introduced next-generation sequencing (NGS) based detection of TP53 single-nucleotide variants (SNV) as an independent high-risk factor. However, most published data on TP53 SNVs in MM derive from exploratory research studies using NGS interpreta...

S. Beer, Elisa Seneca, G. Bertuglia et al. · 0 citations
Open access Sep 2026

Clinical, cytogenetic, and germline genetic determinants of arterial thromboembolism in IMiD-treated multiple myeloma

Immunomodulatory drugs (IMiDs) are associated with an increased risk of arterial thromboembolism (ATE) in multiple myeloma (MM), but determinants and mechanisms remain poorly defined. We evaluated incidence, timing, and clinical risk factors in 4287 patients with newly diagnosed MM from the Myeloma-XI-trial; all re...

S. Beer, D. Cairns, M. Went et al. · 0 citations

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