Pediatric astrocytomas are characterized by increased molecular and clinical heterogeneity with epigenetic alterations contributing to aggressiveness and therapy resistance. The repressive histone mark H4K20 trimethylation (H4K20me3) and the methyltransferase SUV4–20H2 (KMT5C) are critical regulators of chromatin integ...
A. Giannopoulou, Elisavet Kosma, Dimitrios S. Kanakoglou et al.· Neurotherapeutics· 0 citations
Brain aging is characterized by extensive and dynamic epigenetic changes that reshape chromatin architecture and influence gene regulatory networks, leading to deregulation of transcriptional programs essential for neuronal survival, synaptic plasticity, and cognitive function. Emerging studies highlight the pivotal re...
Maria A Katsianou, E. Vetsika, Mariam Markouli et al.· Biomolecules· 0 citations
Brain aging and age-associated neurological diseases, such as Alzheimer's Disease (AD), Parkinson's Disease (PD), and Amyotrophic Lateral Sclerosis (ALS), are largely attributed to epigenetic drift which is characterized by the gradual accumulation of alterations in neural cell methylation patterns over time. These met...
Alkinoos A. Armoundas, C. Piperi· Mechanisms of Ageing and Dev...· 0 citations
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