Author

C. R. Wayne

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Open access Oct 2026

Chemical proteomics reveals post-translational remodeling of endosomal pathways during macrophage activation

Macrophages are central regulators of innate immunity, yet the post-translational mechanisms that enable rapid inflammatory responses remain incompletely understood. Here, we integrated transcriptomics, unenriched proteomics, phosphoproteomics, metabolomics, and cysteine reactivity profiling to comprehensively characte...

Tiffany L. Zhang, Henry Sanford, Railia Gabbasova et al. · bioRxiv · 0 citations

Open access Aug 2026

Th17 effector cytokines induce shared and distinct microglial and endothelial cell responses in a mouse model for post-streptococcal encephalitis

Group A Streptococcus (GAS) infections cause neuropsychiatric complications in children, but the mechanisms linking peripheral infection to brain dysfunction remain unclear. Using mouse genetics, single-cell RNA sequencing, and spatial transcriptomics, we show that GAS infections induce inflammatory transcriptional pro...

C. R. Wayne, U. Akcan, Travis E. Faust et al. · Nature Communications · 0 citations