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Author

C. Ren

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Aug 2026

Targeting GEM Reprograms Macrophages and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma.

GTP-binding protein overexpressed in skeletal muscle (GEM) is identified as a tumor cell-intrinsic regulator associated with poor response to anti-PD-L1 therapy in ESCC and a GEM-SERPINE1-LRP1 signaling axis that drives macrophage-mediated immune suppression is defined.

Lin-Feng Wu, C. Ren, Yi-Fei Zhang et al. · 0 citations
Aug 2026

AKAP13 regulates GLI1/ULK1 axis and drive tumor resistance to next-generation HER2-targeted therapies

It is reported that primary HER2-specific targeted therapy (tucatinib) resistant or sensitive breast cancers derived from clinical trial patients exhibited differential protein profiles and was proposed as a promising therapeutic strategy for HER2-positive breast cancer.

Qing Guo, Xinyu Chen, Lin-Feng Wu et al. · 0 citations

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