Open access
Oct 2026
APOE-ε4 links CD8+ T cell infiltration to white matter inflammation in Alzheimer’s disease
APOE-ε4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD) and has been linked to immune dysregulation, yet its impact on adaptive immunity remains poorly defined. We profiled adaptive immune changes in human APOE-ε3 and APOE-ε4 knock-in (KI) mice using mass cytometry (CyTOF). To assess brain...
Sem Halters, J. H. Wildeman, H. van der Stok et al.
· Molecular Neurodegeneration... · 0 citations