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Open access Aug 2026

Photocontrolled Isomerization Pathways of Tolylsulfonyl- and Pyrene-Linked Norbornadiene Systems Driven by Absorption Band Targeting

Norbornadiene (NBD) photoswitches are promising for molecular solar energy and information storage, as they isomerize to quadricyclane (QC) after absorbing irradiation energy. Here, we report pyrene-linked tolylsulfonyl-substituted NBD hybrids that enable wavelength-selective back-isomerization from QC to NBD. Using fe...

Da-Zhong Sun, Daniel Krappmann, Christoph Oleszak et al. · 0 citations
Aug 2026

Structure-first design of a photoswitchable JAK2 inhibitor candidate with isomer-selective binding.

This work establishes a generalizable in silico framework for designing photoswitchable kinase inhibitor candidates with built-in functional asymmetry, highlighting the potential of computational approaches to guide photopharmacological ligand design.

Shelby R. Kell, Austin D. Barkley, C. Slavov · 0 citations

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