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C. Somaiya

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Sep 2026

Synthesis and Computational Evaluation of Substituted Analogues of 4-Sulfonamide Phenylhydrazones as Potential Anticancer Agents: Molecular Docking, Physicochemical Properties, ADME-Tox, and DFT Analysis.

INTRODUCTION Ten derivatives of benzenesulfonamide (SBB-1 to 10) have been synthesized via the condensation of terminal ketone and aldehyde with aromatic 4-sulfonamide phenylhydrazine. METHODS 1H NMR, 13C NMR, IR, UV, and GC-MS were used to confirm the synthesized derivatives. The in vitro cytotoxicity of the synthes...

D. Upadhyay, Drashti Thanki, C. Somaiya · 0 citations
Aug 2026

Potential c-Met-targeted pyrazole-pyridine-oxadiazole hybrids: synthesis, anticancer activity, and computational rationale.

Findings identify 10d as a promising scaffold for further optimization and biological evaluation because it has the smallest HOMO-LUMO gap and highest chemical softness, consistent with its superior activity.

Prince A. Dave, Jay B. Maheta, Darshna K. Lakhnotra et al. · 0 citations

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