Open access
Aug 2026
M5542, a bifunctional fusion protein targeting CD80, CD86, and OX40L that modulates excessive T-cell activity: a preclinical proof-of-concept study
The bifunctional M5542 blocked CD28 and OX40-mediated T-cell inflammation with greater immunomodulatory activity than monofunctional agents and in some assays comparable to or better than the combination of the monofunctional agents.
Michelle Downing, Allison F. Christiaansen, Ling Zhang et al.
· Frontiers in Immunology · 0 citations