Extracerebral microvascular burden links to dementia risk and brain structural changes: Evidence from a large‐scale cohort study
The contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.
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The contribution of extracerebral microvascular disease (MVD) burden to dementia risk remains unclear.
A genetic comorbidity framework in which shared genetic liability, largely driven by pleiotropic loci, contributes to the co-occurrence of SRDs and CVD is supported and candidate genes and biological processes for future experimental studies are highlighted.
The findings delineate etiologically and clinically distinct MASLD subtypes, reveal protein-mediated pathways to systemic diseases, and inform biologically guided prevention strategies.
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