C. Sussman

Evidence for a tubular basement membrane–cilia connection in autosomal dominant polycystic kidney disease pathogenesis

Using in vivo, ex vivo, tubule-on-chip, and cellular models of ADPKD, Mazloum and colleagues connect cilia-dependent tubule dilation and TBM thinning to early-stage cystogenesis and identify a cilia-dependent TBM remodeling expression signature in affected tubules.