C. Swanton

Impact of Multi-Cancer Early Detection Test on Late-Stage Cancer Diagnosis

Background NHS-Galleri, a randomized controlled trial, evaluates the clinical utility of a blood-based multi-cancer early detection (MCED) test added to usual care among individuals aged 50-77 years in England. Methods Peripheral blood was collected at up to 3 annual visits. Following baseline blood collection, partici...

The long return on discovery science in cancer therapeutics

Integrated MB-PhD training is a long-term investment in the clinician-scientist workforce

Background: Clinician-scientists translate clinical observation into discovery, trials, and policy, yet this workforce is shrinking across health systems worldwide. Integrated MB-PhD training, pausing medical training to complete a PhD before clinical exposure or specialisation, is one route into this career. We aimed...

Charting intratumor heterogeneity from bench to bedside

The current understanding of heterogeneity and evolution is synthesized and it is discussed how these insights can inform the development of evolution-aware diagnostic and therapeutic strategies.

Inverted logic of ecDNA localization converts nuclear periphery into oncogenic transcription hubs in cancer

It is shown that ecDNAs, in contrast to chromosomal DNA, preferentially localize to the nuclear periphery yet resist peripheral gene silencing, and single-molecule multi-omic sequencing and imaging-based CRISPR screening demonstrate enhanced ecDNA hub formation, H3K27ac and H3K9me3 bivalency, late DNA replication, long...