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C. von Spee-Mayer

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Open access Oct 2026

Safety and pharmacokinetics of inhaled aloxistatin: A first-in-human phase 1 dose escalation trial.

AIMS Aloxistatin (E64d) is a membrane-permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first-in-human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers. METHODS In t...

S. Fähndrich, Franziska Friedrich, Daniel Soriano et al. · 0 citations

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