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Author

C. Wen

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Open access Sep 2026

Determination of Hecogenin in Mouse Blood by UPLC-MS/MS and Applied to a Pharmacokinetic Study.

Hecogenin, a steroidal sapogenin from agave plants, exhibits anti-inflammatory, anti-tumor, gastroprotective, and diuretic activities. A sensitive ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for quantifying hecogenin in mouse whole blood using swertisi...

Yu-Jie Hu, Lei Zhu, Xue-Ying Xiang et al. · 0 citations
Open access Sep 2026

Integrated clinical and cellular analysis reveals ferroptosis as a key mechanism in early diquat poisoning.

The early pathogenic mechanisms underlying human diquat (DQ) poisoning remain incompletely understood. This study integrated retrospective clinical analysis, exploratory serum metabolomics, and in vitro experiments to characterize early metabolic disturbances and investigate potential cell-death mechanisms associated w...

Fei-Yan Lin, C. Wen, Jun-Liang Lin et al. · 0 citations
Open access Jul 2026

Development and Validation of a UPLC-MS/MS for Determination of Loureirin D in Rat Plasma and Its Application to Pharmacokinetics.

A sensitive and high-throughput ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) method was developed for the quantitative analysis of loureirin D in rat plasma with only 50 μL of sample per assay and proved to be linear in the concentration range of 2-2400 ng/mL.

Yi Zhou, Yuxin Wu, Chenyao Xu et al. · 0 citations

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