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Open access Sep 2026

Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease

Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is a key mediator of apolipoprotein E4...

P. Bhattarai, E. Yılmaz, Elif Öykü Cakir et al. · 1 citation
Open access Sep 2026

A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions

Macrophages are among the most abundant immune cells in the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME) and play a key role in regulating the immunosuppressive niche that facilitates tumor growth. Although recent three-dimensional (3D) culture systems using patient-derived materials have advanc...

Julius Thyen, V. A. Sioson, Daniel Haak et al. · 0 citations

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