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Review Open access Oct 2026

Metabolic dysfunctions in pancreatic ductal adenocarcinoma: Pathogenic mechanisms and therapeutic implications.

Pancreatic ductal adenocarcinoma (PDAC) remains a highly aggressive malignancy characterized by a dismal prognosis and profound resistance to conventional therapies. Emerging evidence highlights systemic metabolic dysfunctions including obesity, dyslipidemia, type 2 diabetes mellitus (T2DM), and non-alcoholic fatty pan...

R. Rodrigues, Raquel Soares, M. H. Vasconcelos et al. · 0 citations
Open access Oct 2026

Differentiation of Human Glioblastoma Stem Cells as a Prospective Tool to Find New Biomarkers and Molecular Targets: A Proteomic and Lipidomic Approach

Although glioblastoma stem cells (GSCs) constitute a small subpopulation of this highly heterogeneous brain cancer, they are widely recognised as key drivers of tumour recurrence after surgical resection and resistance to radiotherapy and chemotherapy. Differentiation of GSCs has, therefore, emerged as a strategy to in...

A. Cardoso, D. Serra, C. Xavier et al. · 0 citations

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