Author

C. Zheng

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Open access Jul 2026

Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer’s disease lipid-processing microglia

Together, these results advance a described disease-associated microglial state into a reproducible, mechanistically framed regulatory model, providing candidate regulators, upstream ligands, and pharmacological probes for functional validation.

C. Zheng, Tianhua Zhai, Fang-Yuan Zhang et al. · bioRxiv · 0 citations

Open access Aug 2026

Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases

Polygenic and proteomic risk scores are both proposed for pre-symptomatic stratification, yet the extent to which they provide overlapping or complementary information has not been measured across neurodegenerative disease. To quantify this overlap, we define absorption as the fraction of a polygenic score's predictive...

C. Zheng, M. Shivakumar, L. Shen et al. · medRxiv · 0 citations