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Open access Sep 2026

641. Microglial osteopontin is required for myelin structural integrity during brain development

Abstract Background Microglia play essential roles in brain development, including regulation of synaptic pruning, phagocytosis, and myelination. A distinct population of white matter–associated microglia at early postnatal development stage in mouse brain expresses high levels of osteopontin (OPN, Spp1), a multifuncti...

G. Nilsson, C. Zhu, J. Leavenworth et al. · 0 citations
Open access Sep 2026

642. Lithium mitigates autism-like behaviors and neuroinflammation in a valproic acid-induced rat model of autism spectrum disorder

Abstract Background Autism Spectrum Disorder (ASD) is a neurodevelopmental condition marked by social interaction deficits, communication challenges, and repetitive behaviors. The prevalence of ASD has increased significantly. Despite the growing recognition of ASD, effective pharmacological treatments for core symptom...

C. Zhu, Y. Chen, L. Zhang et al. · 0 citations

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