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C. Zuurbier

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Review Open access Aug 2026

NLRX1 emerges as the only observed essential regulator of the mPTP, challenging mPTP inhibition as a valid target of cardioprotection

It is proposed that NLRX1 is the only currently identified protein that is strictly required for mPTP opening, and that indiscriminate inhibition of the mPTP is unlikely to represent a universally effective cardioprotective strategy against I/R injury.

Kielen R. Zuurbier, C. Zuurbier · 0 citations

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