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Çağrı Özkurt

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Oct 2026

Single-cell gene networks nominate IKZF1 as an Alzheimer's disease microglial regulator.

BackgroundMicroglia drive neuroinflammation in Alzheimer's disease (AD), yet no approved therapy targets this compartment. Human genome-wide association studies consistently implicate innate immune loci in AD risk, establishing microglial transcriptional programs as therapeutically relevant but pharmacologically undere...

Çağrı Özkurt · 0 citations
Open access Jul 2026

Single-cell gene networks nominate IKZF1 as an Alzheimer’s microglial regulator

IKZF1 is prioritised as a candidate late-disease microglial TF, supported by six convergent evidence dimensions including independent bulk replication, and low-confidence repurposing hypotheses requiring experimental validation.

Çağrı Özkurt · 0 citations

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