Sep 2026
Secretory expression of tetrameric neuraminidase enhanced by signal peptide optimization elicits robust immunity against influenza infection in mice.
Neuraminidase (NA), a key surface glycoprotein of influenza viruses, represents a more conserved antigenic target than hemagglutinin (HA) and has attracted interest as a potential target for vaccines with broader protective capacity. Nevertheless, the inefficient secretory production of tetrameric NA that maintain tetr...
Li-Sha Deng, Xian-Miao Ye, Xin Chen et al.
· Vaccine · 0 citations