Cai-Xia Yan

PBPK modeling of intravenous/oral acetaminophen in healthy and pregnant individuals.

BACKGROUND Drug metabolism may be influenced by pregnancy. Use of acetaminophen (APAP) is prevalent among pregnant women, necessitating the development of effective methods for predicting its in-vivo disposition. OBJECTIVES A whole physiologically based pharmacokinetic model was developed to predict the pharmacokinet...