Enantioselective Synthesis of Chiral 1,4-Dicarbonyls Bearing All-Carbon Quaternary Stereocenters via Photoredox/Nickel Dual Catalyzed Tandem Radical Addition/Oxidation.
The asymmetric synthesis of 1,4-dicarbonyl compounds bearing all-carbon quaternary stereocenters remains a significant challenge in organic synthesis. Herein, we report a photoredox/nickel dual-catalyzed tandem radical addition and oxidation protocol that directly converts β-keto esters and styrenes into enantioenriche...