The oncogenic mechanisms of fumarate and itaconate are summarized, viable strategies to address technical hurdles in studying non-enzymatic protein modifications are proposed and new directions for the clinical treatment of tumors are offered through targeted inhibition of fumarate and itaconate.
Yi-Dan Fan, Han-Qiu Zhang, Jinkun Qin et al.· Seminars in Oncology· 0 citations
An overview of current progress in targeted therapies and immunotherapy for breast cancer, highlighting their mechanisms, clinical utility, and challenges is provided.
Song Wu, Pangzhou Chen, Wen Zhou et al.· Chinese Medical Journal· 0 citations
This study comprehensively maps the coevolution of malignant thyrocyte plasticity and the immunosuppressive metastatic niche in thyroid cancer and provides a robust molecular rationale for developing next-generation immunotherapeutic strategies tailored to thyroid cancer.
Shu-hang Xu, Yaorong Su, Senmin Zhang et al.· Oncoimmunology· 0 citations
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