Benzodiazepines and GABAA receptor subtypes: Effects in open-field, elevated plus maze-discriminative avoidance task, and conditioned place preference in male mice.
The behavioral effects of the novel benzodiazepine-like compounds, HZ-166 and KRM-II-81, which show preferential efficacy for α2/3GABAA receptors, in comparison with the α1GABAA-selective compound, zolpidem, reinforce the role of α1GABAA receptors in benzodiazepine-induced sedation, cognitive impairment, and addiction...