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Review Open access Aug 2026

Comparative pharmacotherapeutic efficacy and dose-related safety profiles of intrathecal baclofen: a systematic review and meta-analysis in neurological spasticity

ITB therapy provides robust anti-spasticity effects mediated through its targeted action on spinal inhibitory circuits, however, the heterogeneity in dosage efficacy suggests etiology-driven differences in GABAB receptor sensitivity or drug distribution.

Hao-Yuan Chen, Hong-Hui Lei, Yang Yu et al. · 0 citations
Open access Aug 2026

Early high-frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF-κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

High-frequency spinal cord stimulation (HF-SCS) is an effective method for treating neuropathic pain (NP), but its specific mechanism of action in treating spinal cord injury (SCI) remains unclear. The present study aimed to explore the therapeutic effect of early HF-SCS in a rat model of SCI and its potential molecula...

Sitong Su, Tao Liu, Hong-Hui Lei et al. · 0 citations

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