Author

Caleb A. Lareau

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Aug 2026

Reply to: Artefacts in single-cell mtDNA analyses misinform phylogenies

The study does not provide robust evidence that somatic mtDNA variation alone permits the confident inference of highly resolved cellular phylogenies, and reports an order-of-magnitude greater connectedness between cells via mtDNA mutations to resolve detailed phylogenetic trees.

Caleb A. Lareau, M. Chapman, L. Penter et al. · Nature · 1 citation

Open access Sep 2026

Sequence and structural determinants of efficacious de novo chimaeric antigen receptors

This framework synthesizes generative protein design workflows to screen 1,758 newly designed protein binders targeting BCMA, CD19 and CD22 for efficacy in scalable protein-binding, T-cell activation and in vivo killing assays, and develops computational and experimental heuristics to overcome limitations.

Arthur Chow, Ho-Yin Chu, Ruo-Fan Li et al. · Nature Biomedical Engineerin... · 5 citations