Acidity Determination by Spectroscopic and Modeling Methods in Monohydroxy- and Dihydroxy-Substituted Coumarins.
We report the pKa values for 15 mono- and disubstituted hydroxycoumarins determined using UV-vis absorbance spectroscopy and computational methods. Six of these values, including the pKa of 5-hydroxycoumarin, are reported for the first time. While the primary focus is on the effects of hydroxyl substitution on the benz...