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Caleb J. Frye

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Sep 2026

Abstract B024: The EWSR1 low complexity domain drives cooperative DNA binding of EWSR1::FLI1 to multiple GGAA repeats

Ewing Sarcoma is defined by its hallmark mutation, a t(11;22)q24;q12) translocation which results in fusion of the EWSR1 and FLI1 genes. The fusion product, EWSR1::FLI1, contains the N-terminal low complexity domain (LCD) of EWSR1 and the DNA-binding Domain (DBD) of FLI1. EWSR1::FLI1 binds at microsatellites (µsats),...

Caleb J. Frye, R. Zhou, Lexis R. Rice et al. · 0 citations

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