Calvin C. Perdigao

Structural insights into target detection by the Serratia type III CRISPR complex and its deployment in SNP identification.

Type III CRISPR systems utilize a complex containing Cas10, additional Cas proteins and a crRNA to detect foreign transcripts. Upon detection, Cas10 synthesizes cyclic oligoadenylates (cOA), signaling molecules that coordinate interference by stimulating downstream enzymes with DNase, RNase, protease or other activitie...