Open access
Oct 2026
Domain-autonomous MKLP1 modules divergently regulate mitotic fidelity and polyploidy in a holocentric system
Summary While the kinesin MKLP1 is a well-established regulator of cytokinesis, whether its individual domains possess autonomous functions has remained unexplored. Here, using the holocentric Bombyx mori BmN4 system, we show that isolated head, stalk, and tail domains of MKLP1 exhibit distinct subcellular localization...
Bing Zhang, Xiao-Ning Liu, Mei-Ting Song et al.
· iScience · 0 citations