Sep 2026
α7 Nicotinic Acetylcholine Receptor Activation Promotes Anxiety- and Depressive-Like Behaviors Associated With CREB/CRH Signaling in the Hypothalamic Paraventricular Nucleus.
It is found that pharmacological activation of α7 nAChR with PNU282987 induced anxiety- and depressive-like behaviors under control conditions and further exacerbated behavioral abnormalities following chronic restraint stress (CRS), without significantly affecting locomotor activity.
Can-Mao Wang, Rong-Tian Li, Yu-Fan Wu et al.
· Neuropharmacology · 0 citations