Canquing Yu

Incidence patterns and genetic validation of primary glaucoma subtypes among 1 million adults in China and the UK.

BACKGROUND/AIMS Primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) are distinct diseases, yet many glaucoma cases in population-based datasets lack subtype specification. We assessed incidence patterns of glaucoma subtypes in China and the UK and used genetic evidence to infer the likely subty...

Validation and Comparison of 10-Year Cardiovascular Risk Prediction Models in Two Chinese Prospective Cohorts: The General Population and Patients With Type 2 Diabetes.

BACKGROUND To evaluate and recalibrate commonly used 10-year cardiovascular disease (CVD) risk prediction models in two Chinese cohorts: the general population and adults with type 2 diabetes. METHODS We analysed data from the Wuzhong subcohort of the China Kadoorie Biobank (CKB) and the Jiangsu Biobank for the Preve...

Revealing genetic foundations underlying cardiometabolic traits: integrating twin and GWAS data in Asian populations.

Associations of long-term exposure to ambient air pollution with fracture risk and bone mineral density: A cohort study of 0.5 million Chinese adults.

BACKGROUND Evidence regarding the effects of air pollution on bone damage remains limited and inconclusive. We aimed to investigate the individual and combined associations of long-term exposure to ambient air pollutants with fracture risk and bone mineral density (BMD). METHODS This study included 490,172 participan...

Smoking, Solid Fuel Use for Cooking, and Cancer Mortality: A Prospective Cohort Study in Southwestern China.

Smoking and solid fuel are common exposures among Chinese adults, yet evidence regarding their associations with cancer mortality remains inconsistent, and their joint effects are insufficiently studied. Using data from the Pengzhou site of the China Kadoorie Biobank in Sichuan Province, we applied Cox proportional haz...

Adiposity and risk of breast cancer in 280 000 Chinese women: a prospective cohort study

Higher levels of general and central adiposity were associated with a higher risk of breast cancer, in both women who were premenopausal and women who were post-menopausal at baseline in this cohort of Chinese women.

Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease.

A role for lipid-driven chronic inflammation in IHD etiology is supported, and treatment strategies simultaneously targeting multiple lipid and inflammation pathways should be prioritized for further research to improve drug treatment of IHD beyond statin therapy.

Learning Human Health and Diseases from 24-hour Wrist Movement

These findings establish 24-hour wrist movement as a rich and scalable source of health information, with the potential to support passive health monitoring and disease prediction at population scale, and establish Sensori, a self-supervised foundation model that learns general-purpose health representations directly f...

Long-term exposure to air pollution, proteomic aging clocks, and liver-related outcomes in Chinese adults.

Long-term air pollution was associated with higher risks of clinically significant liver-related outcomes and a possible role of proteomic aging in the association between air pollution and liver-related outcomes is suggested, warranting further investigation.