Cao-Kai Zhu

Substrate-pocket reshaping of an (R)-selective transaminase enables efficient asymmetric synthesis of (R)-3-amino-1-butanol.

(R)-Selective ω-transaminases are valuable biocatalysts for the synthesis of chiral amines and pharmaceutical intermediates, but their practical application is often limited by insufficient catalytic efficiency, poor operational stability and unfavorable reaction equilibrium. Here, an Actinomycete-derived (R)-selective...