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Author

Cara Guernsey-Biddle

1 paper indexed here

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Open access Aug 2026

Antibody-drug conjugate combination therapy targeting LGR5 and MET with different payloads enhances efficacy in preclinical colorectal cancer models

Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) is a marker of cancer stem-like cells frequently upregulated in colorectal cancer (CRC) with lower expression in normal tissues, making it a favorable target for antibody-drug conjugates (ADCs). ADCs combine antibody specificity with potent cytotoxic pa...

Shraddha Subramanian, Peyton C. High, Cara Guernsey-Biddle et al. · 0 citations

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