Open access
Aug 2026
Conservation and divergence in the allosteric architectures of five human protein kinases
The activity and abundance of >160,000 variants are quantify the activity and abundance of >160,000 variants to construct complete maps of the energetic and allosteric architectures of five human kinase domains: SRC, FGR, JNK2/MAPK9, ZAK/MAP3K20, and TSSK2.
Carla Folgado, Antoni Beltran, Ben Lehner
· bioRxiv · 0 citations