Author

Carlos J. Ciria-Gil

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Open access Aug 2026

Genome-Scale Codon Deoptimization Enables Attenuation of Rift Valley Fever Virus

Proof of concept is provided for the use of codon deoptimization (CD) as a rational strategy to generate attenuated RVFV, for the development of next-generation vaccines against this zoonotic threat.

Sandra Moreno, Alejandro Cenalmor, Celia Alonso et al. · bioRxiv · 0 citations

Review Open access Jul 2026

Pre-existing and Cross-Reactive Immunity to Avian Influenza H5N1 in Humans: Implications for Pandemic Risk and Vaccine Strategies.

Current evidence on cross-reactive and cross-protective immunity to H5N1 in humans, focusing primarily on humoral immune responses is summarized, and particular attention is given to antibodies targeting conserved regions of hemagglutinin (HA) as well as neuraminidase (NA), which may provide heterosubtypic protection.

Iván Sanz-Muñoz, Carlos J. Ciria-Gil, Marta Hernández et al. · Journal of Infection · 0 citations