Carlos Prudêncio

eNOS uncoupling drives oxidative stress and arrhythmogenic vulnerability in experimental hypothyroidism

Aims Cardiac arrhythmias are a major cause of morbidity and sudden cardiac death worldwide, and hypothyroidism has emerged as an important risk factor. Among the mechanisms involved in cardiac electrical stability, nitric oxide (NO) signaling, particularly via endothelial nitric oxide synthase (eNOS), plays a critical...