Carmen Diniz

A Novel Indole-Dihydroisoxazole Compound Activates Apoptotic, Mitochondrial and Autophagy-related Responses in Lymphoid and Myeloid Leukemia Cells.

Isoxazole-derived compounds possess significant pharmacological properties, particularly in the therapy of hematological malignancies. A prominent example is 5-(1-methyl-1H-indol-3-yl)-3-(4-bromophenyl)-4,5-dihydroisoxazole (DHI1), which has previously been reported to exhibit selective cytotoxic activity toward leukem...