Author

Caroline M. O'Rourke

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Review Open access Jul 2026

Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches

We provide an update on the current psychiatric research for DBS and TMS and what the field has learned about causal circuitry implicated in anxiety and anxiety-related disorders. Recent refinement of DBS and TMS techniques have both improved their safety and efficacy as anxiety treatments and elucidated the pathologic...

Caroline M. O'Rourke, Robert L. Selheimer, Casey H. Halpern et al. · Current Psychiatry Reports · 0 citations

Open access Aug 2026

Repositioning of polyubiquitin alters the pathologic tau filament structure.

It is found that polyubiquitinated tau filaments from Alzheimer disease and vacuolar tauopathy human brain tissue exhibit distinct seeding patterns in mice, in association with differences in tau filament ultrastructure determined by cryo-electron microscopy.

Ryohei Watanabe, Benjamin C. Creekmore, Nabil F. Darwich et al. · Nature Structural & Molecula... · 0 citations