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Author

Caroline Neumann

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Review Open access Sep 2026

The NLRP3 inflammasome in physiological and dysfunctional host response in human sepsis and critical illness: a narrative review

The NLRP3 inflammasome is a cytosolic multiprotein complex that serves as a key regulator of innate immunity by reacting to pathogen- and damage-associated signals and orchestrating downstream inflammatory responses. Inflammasome activation induces caspase-1-dependent maturation of interleukin (IL)-1β, IL-18 and gasder...

Caroline Neumann, Florian Hickl, Julia Kemnitzer et al. · 0 citations

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