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Author

Carolyn R. Bertozzi

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Open access Aug 2026

Democratizing LYTACs-A Modular Click Chemistry Platform for the Rapid Assembly of Lysosome-Targeting Chimeras.

A simple, rapid, and modular click chemistry platform for the generation of CI-M6PR-binding LYTACs, which utilizes only commercially available reagents and standard laboratory equipment and allows for the conversion of virtually any antibody into a LYTAC.

Peter A. Szijj, Sherry Li, M. Gilbert et al. · 0 citations
Open access Jul 2026

AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo

This work developed genetically-encoded lysosome targeting chimeras (GELYTACs) that target circulating IgGs for clearance and degradation and establishes GELYTACs as a possible therapeutic modality that is deliverable using genetic medicine approaches.

J. L. Yang, K. Y. Loh, Cindy R. Sandoval Espinoza et al. · 0 citations

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