Open access
Sep 2026
An update on APC I1307K homozygosity: observations from a large multigene panel testing cohort
Numerous studies have demonstrated that Ashkenazi Jewish individuals heterozygous for APC c.3902T > A; p.Ile1307Lys have 1.7-fold increased odds of colorectal adenocarcinoma (CRC). The cancer risk for homozygotes is unknown, and published data is based on small sample sizes. Here, we aim to quantitatively evaluate the...
Leah Zaretsky, Marcy E. Richardson, Taylor Coleman et al.
· Familial Cancer · 0 citations