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Author

Carrie Jonak

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Open access Sep 2026

Blarcamesine improves EEG biomarkers of cortical dysfunction in a mouse model of fragile X syndrome

Background Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism spectrum disorder. Previous studies in the Fmr1 knockout (KO) mouse model of FXS and affected individuals have identified common electroencephalographic (EEG) abnormalities, which constitute biomarkers of cortica...

Carrie Jonak, Samantha A. Assad, D. Binder et al. · 0 citations
Open access Sep 2026

Atlas-Based Electrical Source Imaging for Mouse EEG: Application to an Fmr1 Knockout Model.

Electrical source imaging (ESI) reconstructs where in the brain a scalp EEG signal arises. It is routine in humans but unestablished in the mouse, whose brain is some 3,000 times smaller where it is not obvious that a sparse array can separate one region from another. We built an atlas-based ESI pipeline for 30-channel...

Alex D. Edmondson, Andrew D. Gaulden, Richard K. Lacher et al. · 0 citations
Sep 2026

A cell type-specific switch in GluN2D NMDA receptors drives cortical circuit hyperexcitability and sensory-driven cortical synchronization deficits in a Fragile X Syndrome model.

BACKGROUND Altered sensory processing and sensitivity are prevalent in Fragile X Syndrome (FXS) and may be mediated by dysfunction of cortical circuits. Evidence from individuals with FXS and/or the FXS mouse model, Fmr1 KO, indicates hyperexcitability of sensory cortical circuits, deficits in sensory-driven circuit sy...

Aleya Shedd, Carrie Jonak, Leo Chan et al. · 1 citation

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