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Author

Cas van der Horst

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Oct 2026

Design and Development of New Dual Target Agents, Cannabinoid Subtype 2 Receptor (CB2R) Agonists, and Fatty Acid Amide Hydrolase (FAAH) Inhibitors against Neurodegeneration

As dual modulators of Cannabinoid subtype 2 receptor (CB2R) and fatty acid amide hydrolase (FAAH)an arising therapeutic strategy against diseases based on neuroinflammationwe developed a new series of N-adamantyl-benzamides bearing an anthranilic or salicylic scaffold. Derivatives 18, 22, and 25 emerged as an inter...

Giovanni Graziano, Francesco Mastropasqua, A. Fanizzi et al. · 0 citations
Open access Jul 2026

Automated Parallel Synthesis Accelerates Virtual Screening Hit Discovery

ComBINAUT is an automated parallel synthesis platform that generates diverse chemical scaffolds to accelerate hit validation and refinement, enabling the efficient exploration of chemical space and the rapid discovery of novel ligands.

Sean M. McKenna, M. Šícho, Cas van der Horst et al. · 0 citations

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