Genome-wide CRISPR screen identifies AMBRA1 as a potential biomarker of response to platinum-based therapies in oral squamous cell carcinomas
Summary Oral squamous cell carcinomas (OSCCs) are among the most frequent and lethal cancers worldwide. Advanced stage tumors are still treated with standard chemotherapy; however, most patients develop chemotherapy resistance. To uncover new functional biomarkers of cisplatin response, we performed a synthetic lethali...