Pharmacokinetic Modeling and Dosing Simulations of Temocillin in Children With Urinary Tract Infections.
BACKGROUND Temocillin, active against most extended-spectrum β-lactamases (ESBL)-producing Enterobacterales, is increasingly considered a carbapenem-sparing option for Gram-negative infections. Despite a recommended pediatric dose of 25-50 mg/kg/d in 2 administrations, its pharmacokinetics in children remain ill charac...